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Papers of the Week

Papers: 12 Oct 2019 - 18 Oct 2019

Human Studies


2019 Oct 15

BMC Neurol



Increased activation of the pregenual anterior cingulate cortex to citalopram challenge in migraine: an fMRI study.


Edes A E, McKie S, Szabo E, Kokonyei G, Pap D, Zsombok T, Magyar M, Csepany E, Hullam G, Szabo A G, Kozak L R, Bagdy G, Juhasz G
BMC Neurol. 2019 Oct 15; 19(1):237.
PMID: 31615444.


The anterior cingulate cortex (ACC) is a key structure of the pain processing network. Several structural and functional alterations of this brain area have been found in migraine. In addition, altered serotonergic neurotransmission has been repeatedly implicated in the pathophysiology of migraine, although the exact mechanism is not known. Thus, our aim was to investigate the relationship between acute increase of brain serotonin (5-HT) level and the activation changes of the ACC using pharmacological challenge MRI (phMRI) in migraine patients and healthy controls.