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Papers of the Week

2020 Feb

World Neurosurg


Establishment of a therapeutic ratio for Gamma Knife Radiosurgery of trigeminal neuralgia: The critical importance of biologically effective dose (BED) versus physical dose.


Tuleasca C, Paddick I, Hopewell JW, Jones B, Millar WT, Hamdi H, Porcheron D, Levivier M, Régis J
World Neurosurg. 2020 Feb; 134:e204-e213.
PMID: 31606504.


How variations of treatment time affect the safety/efficacy of Gamma Knife (GK) radiosurgery is a matter of considerable debate. Due to the relative simplicity of treatment planning for trigeminal neuralgia (TN) this question has been addressed in a group of these patients. Using the concept of biologically effective dose (BED) the effect of the two key variables, dose and treatment time have been taken into account.