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Papers of the Week

Papers: 12 Oct 2019 - 18 Oct 2019

Human Studies


2020 Jan

J Neurol



Increased neural connectivity between the hypothalamus and cortical resting-state functional networks in chronic migraine.


Coppola G, Di Renzo A, Petolicchio B, Tinelli E, Di Lorenzo C, Serrao M, Calistri V, Tardioli S, Cartocci G, Parisi V, Caramia F, Di Piero V, Pierelli F
J Neurol. 2020 Jan; 267(1):185-191.
PMID: 31606759.


The findings of resting-state functional MRI studies have suggested that abnormal functional integration between interconnected cortical networks characterises the brain of patients with migraine. The aim of this study was to investigate the functional connectivity between the hypothalamus, brainstem, considered as the migraine generator, and the following areas/networks that are reportedly involved in the pathophysiology of migraine: default mode network (DMN), executive control network, dorsal attention system, and primary and dorsoventral visual networks.