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Papers of the Week

2020 Feb

Eur J Pain



Impact of caloric restriction on peripheral nerve injury-induced neuropathic pain during aging in mice.


De Angelis F, Vacca V, Pavone F, Marinelli S
Eur J Pain. 2020 Feb; 24(2):374-382.
PMID: 31610068.


The incidence of peripheral neuropathy development and chronic pain is strongly associated with the arrival of senescence. The gradual physiological decline that begins after the mature stage produces myelin dysregulation and pathological changes in peripheral nervous system, attributed to reduction in myelin proteins expression and thinner myelin sheath. Moreover in elder subjects, when nerve damage occurs, the regenerative processes are seriously compromised and neuropathic pain (NeP) is maintained. We previously demonstrated that caloric restriction (CR) in adult (4 months) nerve-lesioned mice was able to facilitate remyelination and axons regeneration, to have anti-inflammatory action and to prevent NeP chronification. Here, we show CR therapeutic potential on nerve injury-induced neuropathy in mice at the beginning of the senescence (12 months). Long lasting decrease of hypersensitvity induced by peripheral nerve lesion and powerful reduction of pro-inflammatory circulating agents have been observed. Moreover, our results evidence that CR is able to counteract the aging-related delay in axonal regeneration, enhancing Schwann cells proliferation and accelerating recovery processes. Differently from adults, it does not affect fibres myelination. In light of a continuous growth in elderly population and correlated health problems, including metabolic disorders, the prevalence of neuropathy is enhancing, generating a significant public cost and social concern. In this context energy depletion by dietary restriction can be a therapeutic option in NeP.