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Papers of the Week

2019 Oct 08

Singapore Med J

Anaesthetic modality and post-surgical oncological outcomes for paediatric tumours: is there a link?


Lee S Y, Acharyya S, Tan A W L, Loh A H P
Singapore Med J. 2019 Oct 08.
PMID: 31598733.


Children with solid organ tumours often present for curative surgery. Even with the best surgical technique, micrometastases can occur. Preclinical studies support the postulation that neuraxial anaesthesia maintains the body's immune and inflammatory milieu against metastasis. However, human retrospective adult studies showed varying results, and no study has been done in children. We aim to find out if intraoperative epidural, perioperative opioid and volatile dose are associated with relapse-free survival (RFS) of children with solid organ tumours.