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Papers of the Week

2020 May

Dig Dis Sci



Cholecystokinin Receptor Antagonist Therapy Decreases Inflammation and Fibrosis in Chronic Pancreatitis.


Nadella S, Ciofoaia V, Cao H, Kallakury B, Tucker RD, Smith JP
Dig Dis Sci. 2020 May; 65(5):1376-1384.
PMID: 31598921.


Chronic pancreatitis is associated with recurrent inflammation, pain, fibrosis, and loss of exocrine and endocrine pancreatic function and risk of cancer. We hypothesized that activation of the CCK receptor contributes to pancreatitis and blockade of this pathway would improve chronic pancreatitis.