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Papers of the Week


2019


PLoS One


14


10

Trace amine-associated receptor gene polymorphism increases drug craving in individuals with methamphetamine dependence.

Authors

Loftis JM, Lasarev M, Shi X, Lapidus J, Janowsky A, Hoffman WF, Huckans M
PLoS One. 2019; 14(10):e0220270.
PMID: 31600226.

Abstract

Methamphetamine (MA) is a potent agonist at the trace amine-associated receptor 1 (TAAR1). This study evaluated a common variant (CV) in the human TAAR1 gene, synonymous single nucleotide polymorphism (SNP) V288V, to determine the involvement of TAAR1 in MA dependence.