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Papers of the Week

2019 Nov 07

Clin J Am Soc Nephrol



Associations of Opioid Prescriptions with Death and Hospitalization across the Spectrum of Estimated GFR.


Novick TK, Surapaneni A, Shin J-I, Alexander CG, Inker LA, Wright EA, Chang AR, Grams ME
Clin J Am Soc Nephrol. 2019 Nov 07; 14(11):1581-1589.
PMID: 31582462.


Most opioids undergo kidney excretion. The goal of this study was to evaluate opioid-associated risks of death and hospitalization across the range of eGFR. DESIGN,: The study population included adult primary care patients in Geisinger Health (Danville, PA) between 2008 and 2017. People receiving their first opioid prescription were propensity matched to people receiving NSAIDS (and, in sensitivity analysis, gabapentinoids) and the risk of death and hospitalization were compared, classifying opioid medication exposure as time-varying daily oral morphine milligram equivalents (MMEs) across time-varying eGFR.