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Papers of the Week

2019 May-Jun

Pain Rep



Designing and conducting proof-of-concept chronic pain analgesic clinical trials.


Campbell CM, Gilron I, Doshi T, Raja S
Pain Rep. 2019 May-Jun; 4(3):e697.
PMID: 31583338.


The evolution of pain treatment is dependent on successful development and testing of interventions. Proof-of-concept (POC) studies bridge the gap between identification of a novel target and evaluation of the candidate intervention's efficacy within a pain model or the intended clinical pain population.