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Papers of the Week

2019 May-Jun

Pain Rep



Active metabolites of dipyrone induce a redox-dependent activation of the ion channels TRPA1 and TRPV1.


Schenk S A, Dick F, Herzog C, Eberhardt M J, Leffler A
Pain Rep. 2019 May-Jun; 4(3):e720.
PMID: 31583344.


The nonopioid analgesic and antipyretic dipyrone (metamizol) is frequently used worldwide. Dipyrone is a prodrug, and the metabolites 4-N-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA) seem to induce analgesia and antipyresia in part by inhibiting cyclooxygenase. In mice, however, the analgesic effect of dipyrone also seems to depend on the ion channel TRPA1. In this study, we explored the effects of dipyrone and its active metabolites on recombinant and native TRPA1 and TRPV1 channels.