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Papers of the Week

2019 May-Jun

Pain Rep



Does toe clipping for genotyping interfere with later-in-life nociception in mice?


Frezel N, Kratzer G, Verzar P, Bürki J, Weber FA, Zeilhofer H U
Pain Rep. 2019 May-Jun; 4(3):e740.
PMID: 31583355.


Genetically modified mice are widely used in studies on human and animal physiology and pharmacology, including pain research. The experimental design usually includes comparisons of genetically modified mice with wild-type littermates, requiring biopsy material for genotyping and methods for unequivocal identification of individual mice. Ethical standards and, in some countries, legislation require that both needs are reached with a single procedure. Clipping of the most distal phalanx of up to two toes per paw (toe clipping) is the favored procedure in most research fields, but it may be problematic in sensory physiology and pain research.