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Papers of the Week

2019 Sep 14

World J Gastroenterol



Effect of Tong Xie Yao Fang on endogenous metabolites in urine of irritable bowel syndrome model rats.


Zhao X-Y, Wang J-W, Yin Y, Li K, Zhang M, Yan F-P
World J Gastroenterol. 2019 Sep 14; 25(34):5134-5151.
PMID: 31558862.


Tong Xie Yao Fang is a representative traditional Chinese prescription for the treatment of liver and spleen deficiency, abdominal pain and diarrhea. It has a unique function in the treatment of gastrointestinal dysfunction including irritable bowel syndrome (IBS), is a common functional bowel disease. Its main symptoms are recurrent abdominal pain, diarrhea, constipation or alternations between diarrhea and constipation. There are obvious differences in metabolites between TCM syndromes. By comparing the body fluid metabolism maps of model animals, metabolomics can discover disease biomarkers, analyze the differences in metabolic pathways and understand the pathological process and the metabolic pathways of substances in the body. Thus, the evaluation of animal models tends to be comprehensive and objective. This may provide further understanding between the interaction between Tong Xie Yao Fang and the IBS model.