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Papers of the Week

2019 Dec

J Clin Pharm Ther



Bromadiolone poisoning leading to subarachnoid haemorrhage: A case report and review of the literature.


Zuo W, Zhang X, Chang J-B, Ma W-B, Wei J-J
J Clin Pharm Ther. 2019 Dec; 44(6):958-962.
PMID: 31556967.


Many cases of rodenticide poisoning have been reported. Bromadiolone, often called a super-warfarin, is a second-generation dicoumarin rodenticide with long half-life. The main clinical manifestations of bromadiolone poisoning are excessive or inappropriate bleeding of skin mucosa, digestive tract and urinary tract. However, the phenomenon of central nervous system (CNS) toxicity is an uncommon medical emergency. We present a case of SAH and intracerebral haematoma mediated by bromadiolone intoxication, revealing that bromadiolone poisoning might cause intracerebral haematoma.