I am a
Home I AM A Search Login

Papers of the Week


Papers: 21 Sep 2019 - 27 Sep 2019


Animal Studies, Pharmacology/Drug Development

PAIN TYPE:
Migraine/Headache


2019 Dec


Cephalalgia


39


14

CGRP-dependent and independent mechanisms of acute and persistent post-traumatic headache following mild traumatic brain injury in mice.

Authors

Navratilova E, Rau J, Oyarzo J, Tien J, Mackenzie K, Stratton J, Remeniuk B, Schwedt T, Anderson T, Dodick D, Porreca F
Cephalalgia. 2019 Dec; 39(14):1762-1775.
PMID: 31550910.

Abstract

Acute and persistent post-traumatic headache are often debilitating consequences of traumatic brain injury. Underlying physiological mechanisms of post-traumatic headache and its persistence remain unknown, and there are currently no approved therapies for these conditions. Post-traumatic headache often presents with a migraine-like phenotype. As calcitonin-gene related peptide promotes migraine headache, we explored the efficacy and timing of intervention with an anti- calcitonin-gene related peptide monoclonal antibody in novel preclinical models of acute post-traumatic headache and persistent post-traumatic headache following a mild traumatic brain injury event in mice.