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Papers of the Week

Papers: 21 Sep 2019 - 27 Sep 2019

Human Studies, Pharmacology/Drug Development

2020 Feb 01

Pain Med



Human Abuse Potential of Oral NKTR-181 in Recreational Opioid Users: A Randomized, Double-Blind, Crossover Study.


Ge X, Henningfield JE, Siddhanti S, Jobes J, Lu L, Xie S, Ziola M, Kelsh D, Vince B, Di Fonzo CJ, Tagliaferri M, Zalevsky J, Doberstein SK, Hoch U, Eldon MA
Pain Med. 2020 Feb 01; 21(2):e114-e126.
PMID: 31553457.


To evaluate the human abuse potential, pharmacokinetics, pharmacodynamics, and safety of oral NKTR-181 (oxycodegol), a novel full mu-opioid receptor agonist, relative to oral oxycodone.