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Papers of the Week

Papers: 21 Sep 2019 - 27 Sep 2019

Animal Studies, Pharmacology/Drug Development

2019 Sep 20

Reg Anesth Pain Med

AMP-activated protein kinase (AMPK) activator drugs reduce mechanical allodynia in a mouse model of low back pain.


Das V, Kroin JS, Moric M, McCarthy RJ, Buvanendran A
Reg Anesth Pain Med. 2019 Sep 20.
PMID: 31541009.


Intervertebral disc herniation is one of the common causes of low back pain. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) activator drugs have been shown to reduce pain in several animal models. The present study examines if early treatment with the drug metformin, an indirect AMPK activator, and/or O304, a new direct AMPK activator, can reduce the mechanical hypersensitivity that develops after lumbar disc puncture in mice.