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Papers of the Week

2019 Nov

Adv Ther



Expert Consensus on Clinical Use of an Orally Administered Dexketoprofen Plus Tramadol Fixed-Dose Combination in Moderate-To-Severe Acute Pain: A Delphi Study.


Varrassi G, Coaccioli S, De-Andrés J, Hanna M, Macheras G, Montero A, Perrot S, Piras V, Scarpignato C
Adv Ther. 2019 Nov; 36(11):3174-3185.
PMID: 31535328.


In 2016, the orally administered fixed-dose combination of dexketoprofen 25 mg and tramadol 75 mg (DKP/TRAM FDC) was approved in Europe for short-term treatment of moderate-to-severe acute pain, an indication that encompasses a wide range of post-operative and non-surgical painful conditions. This has suggested the necessity to have a clearer indication on its clinical use, with the support of expert pain clinicians, working in different medical specialities, and reinforced by the data present in the literature.