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Papers of the Week


2019 Nov


Pharmacol Res


149

IL-6 INVOLVEMENT IN PAIN, FATIGUE AND MOOD DISORDERS IN RHEUMATOID ARTHRITIS AND THE EFFECTS OF IL-6 INHIBITOR SARILUMAB.

Authors

Atzeni F, Nucera V, Masala I F, Sarzi-Puttini P, Bonitta G
Pharmacol Res. 2019 Nov; 149:104402.
PMID: 31536783.

Abstract

Interleukin 6 (IL-6) is a pleiotropic cytokine that plays a role in the neuroendocrine system, insulin resistance, lipid metabolism, vascular disease, mitochondrial activities, neuropsychological behaviour, and also mediates communications between the immune and central nervous system (CNS). Treatment with anti-IL-6 or anti-IL-6R agents seems to alleviate allodynia and hyperalgesia, so it may be a valid option when treating the many conditions involving pathological pain as rheumatoid arthritis.