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Papers of the Week

Papers: 14 Sep 2019 - 20 Sep 2019

Animal Studies

2019 Nov

J Physiol



Serotonin exerts a direct modulatory role on bladder afferent firing in mice.


Konthapakdee N, Grundy L, O'Donnell T, Garcia-Caraballo S, Brierley SM, Grundy D, Daly DM
J Physiol. 2019 Nov; 597(21):5247-5264.
PMID: 31520534.


Functional disorders (i.e., interstitial cystitis/painful bladder syndrome and irritable bowel syndrome) are associated with hyperexcitability of afferent nerves innervating the urinary tract and the bowel respectively. Various non-5-HT receptor mRNA transcripts are expressed in mouse urothelium and exert functional responses to 5-HT. Whilst 5-HT receptors were not detected in mouse urothelium, 5-HT receptors expressed on bladder sensory neurons plays a role in bladder afferent excitability under both normal conditions and in a mouse model of chronic visceral hypersensitivity (CVH). These data suggest that the role 5-HT receptors play in bladder afferent signaling warrants further study as a potential therapeutic target for functional bladder disorders.