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Papers of the Week

2019 Sep 12

BMC Musculoskelet Disord



Biocompatibility study of different hyaluronan products for intra-articular treatment of knee osteoarthritis.


Yoshioka K, Katayama M, Nishiyama T, Harada K, Takeshita S, Kawamata Y
BMC Musculoskelet Disord. 2019 Sep 12; 20(1):424.
PMID: 31511072.


Intra-articular (IA) injection of hyaluronic acid (HA) (IA-HA) is a well-recognized treatment option for pain associated with symptomatic knee osteoarthritis (OA). IA-HA products differ in their HA content, molecular weight, cross-linking, and source of HA. These differences are assumed to affect the biocompatibility of the IA-HA products once injected inside the knee joint.