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Papers of the Week

Papers: 7 Sep 2019 - 13 Sep 2019

2019 Oct 01

JAMA Neurol



Editor's Pick

Scientific Advances in and Clinical Approaches to Small-Fiber Polyneuropathy: A Review.


Oaklander A L, Nolano M
JAMA Neurol. 2019 Oct 01; 76(10):1240-1251.
PMID: 31498378.


Small-fiber polyneuropathy involves preferential damage to the thinly myelinated A-delta fibers, unmyelinated C sensory fibers, or autonomic or trophic fibers. Although this condition is common, most patients still remain undiagnosed and untreated because of lagging medical and public awareness of research advances. Chronic bilateral neuropathic pain, fatigue, and nausea are cardinal symptoms that can cause disability and dependence, including pain medication dependence.