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Papers of the Week

2019 Sep 04

Reg Anesth Pain Med

Neuromodulatory effects of pudendal nerve stimulation on bladder hypersensitivity are present in opioid-pretreated rats.


Ness T J, McNaught J, Clodfelder-Miller B, Nelson DE, Su X
Reg Anesth Pain Med. 2019 Sep 04.
PMID: 31488554.


Bilateral electrical pudendal nerve stimulation (bPNS) reduces bladder hypersensitivity in rat models and anecdotally reduces pain in humans with pelvic pain of urologic origin. Concomitant opioids are known to alter responses to neuromodulation in some systems. So prior to the development of a clinical trial for purposes of regulatory approval, the preclinical interaction between opioids and stimulation effectiveness was examined.