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Papers of the Week

2019 Sep

Medicine (Baltimore)



Effectiveness of the traditional Japanese Kampo medicine Yokukansan for chronic migraine: A case report.


Akiyama H, Hasegawa Y
Medicine (Baltimore). 2019 Sep; 98(36):e17000.
PMID: 31490382.


The traditional Japanese Kampo medicine Yokukansan (TSUMURA Yokukansan extract granules) was originally used to treat neurosis, insomnia, night crying, and irritability and/or agitation in infants and recently it has also been used for neuropsychiatric symptoms in Alzheimer's disease or other dementia in Japan. Furthermore, several recent studies have reported the efficacy of Kampo medicines for various types of headache. Here, we report a case of severe chronic migraine refractory to prophylactic therapy using various western medicines and Japanese Kampo medicines that had resulted in a leave of absence from work, but for which the frequency and severity were markedly decreased by Yokukansan (2.5 g 3 times/d), enabling the patient to return to work fully.