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Papers of the Week

2019 Sep 03

BMJ Open



Assessing the effectiveness of perioperative s-ketamine on new-onset headache after resective epilepsy surgery (ESPAIN-trial): protocol for a randomised, double-blind, placebo-controlled trial.


Sloekers J C T, Bos M, Hoogland G, Bastiaenen C, van Kuijk S, Theunissen M, Rijkers K, Dings J, Colon A, Rouhl RPW, Schijns O E M G
BMJ Open. 2019 Sep 03; 9(8):e030580.
PMID: 31481375.


Effective treatment of new-onset headache after craniotomy, especially anterior temporal lobectomy (ATL) and amygdalohippocampectomy for drug-resistant temporal lobe epilepsy, is a challenge. The current practice, acetaminophen combined with opioids is often reported by patients as insufficient and sometimes accompanied by opioid-related adverse effects. Based on expert opinion, anaesthesiologists therefore frequently consider s-ketamine as add-on therapy. This randomised parallel group design trial compares s-ketamine with a placebo as add on medication to a multimodal pain approach.