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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Trial of SAGE-217 in Patients with Major Depressive Disorder.

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2019 Sep 05


N Engl J Med


http://www.ncbi.nlm.nih.gov/pubmed/31483961?dopt=Abstract


381


10

Trial of SAGE-217 in Patients with Major Depressive Disorder.

Authors

Trial of SAGE-217 in Patients with Major Depressive Disorder.
Gunduz-Bruce H, Silber C, Kaul I, Rothschild AJ, Riesenberg R, Sankoh AJ, Li H, Lasser R, Zorumski CF, Rubinow DR, Paul SM, Jonas J, Doherty JJ, Kanes SJ
N Engl J Med. 2019 Sep 05; 381(10):903-911.
PMID: 31483961.

Abstract

Altered neurotransmission of γ-aminobutyric acid (GABA) has been implicated in the pathogenesis of depression. Whether SAGE-217, an oral, positive allosteric modulator of GABA type A receptors, is effective and safe for the treatment of major depressive disorder is unknown.
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