I am a
Home I AM A Search Login

Papers of the Week

Papers: 7 Sep 2019 - 13 Sep 2019

Human Studies


2020 Feb

Br J Dermatol



Small-fiber neuropathy and pruritus: histological patterns of nerve fibers in skin biopsies.


Bonsang B, Brenaut E, Talagas M, Uguen A, Bonsang-Kitzis H, Misery L, Marcorelles P
Br J Dermatol. 2020 Feb; 182(2):504-506.
PMID: 31487389.


Small fiber neuropathy (SFN) is a disease of intraepidermal nerves fibers (IENF) (myelinated Aδ and unmyelinated C-fibers) prevalent in about 53/100,000 people. Mostly idiopathic, SFN can have various etiologies as alcoholism, diabetes, immune-mediated or infectious diseases. SFN commonly affects limbs in a distal to proximal gradient and manifests as various sensory symptoms. The diagnosis of SFN must fulfill following criteria : 1- a symptomatology consistent with neuropathic pains and autonomic complaints; 2- no central or motor involvement; 3- no nervous trunk achievement detected on electromyogram; 4- a reduction of IENF density (IENFD) in the distal area measured on skin biopsy ("gold standard" for diagnosis). This article is protected by copyright. All rights reserved.