I am a
Home I AM A Search Login

Papers of the Week

Papers: 31 Aug 2019 - 6 Sep 2019

Animal Studies

2019 Sep 05




Editor's Pick

A Cold-Sensing Receptor Encoded by a Glutamate Receptor Gene.


Gong J, Liu J, Ronan EA, He F, Cai W, Fatima M, Zhang W, Lee H K, Li Z, Kim G-H, Pipe KP, Duan B, Liu J, Xu SXZ
Cell. 2019 Sep 05; 178(6):1375-1386.e11.
PMID: 31474366.


In search of the molecular identities of cold-sensing receptors, we carried out an unbiased genetic screen for cold-sensing mutants in C. elegans and isolated a mutant allele of glr-3 gene that encodes a kainate-type glutamate receptor. While glutamate receptors are best known to transmit chemical synaptic signals in the CNS, we show that GLR-3 senses cold in the peripheral sensory neuron ASER to trigger cold-avoidance behavior. GLR-3 transmits cold signals via G protein signaling independently of its glutamate-gated channel function, suggesting GLR-3 as a metabotropic cold receptor. The vertebrate GLR-3 homolog GluK2 from zebrafish, mouse, and human can all function as a cold receptor in heterologous systems. Mouse DRG sensory neurons express GluK2, and GluK2 knockdown in these neurons suppresses their sensitivity to cold but not cool temperatures. Our study identifies an evolutionarily conserved cold receptor, revealing that a central chemical receptor unexpectedly functions as a thermal receptor in the periphery.