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Papers of the Week

Papers: 31 Aug 2019 - 6 Sep 2019

Animal Studies


2019 Oct




Exploring the effects of extracranial injections of botulinum toxin type A on prolonged intracranial meningeal nociceptors responses to cortical spreading depression in female rats.


Melo-Carrillo A, Strassman AM, Schain AJ, Noseda R, Ashina S, Adams A, Brin MF, Burstein R
Cephalalgia. 2019 Oct; 39(11):1358-1365.
PMID: 31475573.


Botulinum neurotoxin type A, an FDA-approved prophylactic drug for chronic migraine, is thought to achieve its therapeutic effect through blocking activation of unmyelinated meningeal nociceptors and their downstream communications with myelinated nociceptors and potentially the vasculature and immune cells. Prior investigations to determine botulinum neurotoxin type A effects on meningeal nociceptors were carried out in male rats and tested with stimuli that act outside the blood brain barrier. Here, we sought to explore the effects of extracranial injections of botulinum neurotoxin type A on activation of meningeal nociceptors by cortical spreading depression, an event which occurs inside the blood brain barrier, in female rats.