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Papers of the Week


Papers: 24 Aug 2019 - 30 Aug 2019


Human Studies, Pharmacology/Drug Development


2019


Drug Des Devel Ther


13

Dextromethorphan and memantine after ketamine analgesia: a randomized control trial.

Authors

Martin E, Sorel M, Morel V, Marcaillou F, Picard P, Delage N, Tiberghien F, Crosmary M-C, Najjar M, Colamarino R, Créach C, Lietar B, Brumauld de Montgazon G, Margot-Duclot A, Loriot M-A, Narjoz C, Lambert C, Pereira B, Pickering G
Drug Des Devel Ther. 2019; 13:2677-2688.
PMID: 31447547.

Abstract

Intravenous ketamine is often prescribed in severe neuropathic pain. Oral -methyl-D-aspartate receptor (NMDAR) antagonists might prolong pain relief, reducing the frequency of ketamine infusions and hospital admissions. This clinical trial aimed at assessing whether oral dextromethorphan or memantine might prolong pain relief after intravenous ketamine.