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Papers of the Week

Papers: 24 Aug 2019 - 30 Aug 2019

Human Studies, Pharmacology/Drug Development


Drug Des Devel Ther


Dextromethorphan and memantine after ketamine analgesia: a randomized control trial.


Martin E, Sorel M, Morel V, Marcaillou F, Picard P, Delage N, Tiberghien F, Crosmary M-C, Najjar M, Colamarino R, Créach C, Lietar B, Brumauld de Montgazon G, Margot-Duclot A, Loriot M-A, Narjoz C, Lambert C, Pereira B, Pickering G
Drug Des Devel Ther. 2019; 13:2677-2688.
PMID: 31447547.


Intravenous ketamine is often prescribed in severe neuropathic pain. Oral -methyl-D-aspartate receptor (NMDAR) antagonists might prolong pain relief, reducing the frequency of ketamine infusions and hospital admissions. This clinical trial aimed at assessing whether oral dextromethorphan or memantine might prolong pain relief after intravenous ketamine.