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Papers of the Week


Papers: 24 Aug 2019 - 30 Aug 2019


Human Studies, Pharmacology/Drug Development

PAIN TYPE:
Itch


2019 Dec


J Eur Acad Dermatol Venereol


33


12

Neurokinin 1 receptor antagonists exhibit peripheral effects in prurigo nodularis including reduced ERK1/2 activation.

Authors

Agelopoulos K, Rülander F, Dangelmaier J, Lotts T, Osada N, Metze D, Luger TA, Loser K, Ständer S
J Eur Acad Dermatol Venereol. 2019 Dec; 33(12):2371-2379.
PMID: 31442331.

Abstract

Aprepitant is a neurokinin 1 receptor (NK1R) antagonist used for its antipruritic properties in dermatoses and systemic diseases. The mode of action is still unclear. A peripheral effect is assumed as aprepitant shows efficacy in inflammatory skin diseases including prurigo nodularis (PN).