I am a
Home I AM A Search Login

Papers of the Week

Papers: 17 Aug 2019 - 23 Aug 2019

2019 Aug 19

Syst Rev



A systematic review of experimental methods to manipulate secondary hyperalgesia in humans: protocol.


Madden VJ, Bedwell GJ, Chikezie PC, Rice ASC, Kamerman PR
Syst Rev. 2019 Aug 19; 8(1):208.
PMID: 31426841.


Neuropathic pain affects 7-10% of people, but responds poorly to pharmacotherapy, indicating a need for better treatments. Mechanistic research on neuropathic pain frequently uses human surrogate models of the secondary hyperalgesia that is a common feature of neuropathic pain. Experimentally induced secondary hyperalgesia has been manipulated with pharmacological and non-pharmacological methods to clarify the relative contributions of different mechanisms to secondary hyperalgesia. However, this literature has not been systematically synthesised. The aim of this systematic review is to identify, describe, and compare methods that have been used to manipulate experimentally induced secondary hyperalgesia in healthy humans.