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Papers of the Week

Papers: 17 Aug 2019 - 23 Aug 2019

Human Studies, Pharmacology/Drug Development

2019 Aug 18

BMJ Open



Subcutaneous sumatriptan for the treatment of postcraniotomy pain (SUPS trial): protocol for a randomised double-blinded placebo controlled trial.


Postcraniotomy pain protocols use opioids, which are considered suboptimal analgesia following this procedure. Multimodal analgesia components are sparse. Our null hypothesis states that sumatriptan is not different to placebo in addition to usual intravenous opioids, for the treatment of acute postcraniotomy pain.