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Papers of the Week

Papers: 17 Aug 2019 - 23 Aug 2019

Animal Studies

2019 Jan-Dec

Mol Pain


Expression of a novel versican variant in dorsal root ganglia (DRG) from spared nerve injury (SNI) rats.


Bogen O, Bender O, Alvarez P, Kern M, Tomiuk S, Hucho F, Levine J
Mol Pain. 2019 Jan-Dec; 15:1744806919874557.
PMID: 31429356.


The size and modular structure of versican and its gene suggests the existence of multiple splice variants. We have identified, cloned and sequenced a previously unknown exon located within the non-coding gene sequence downstream of exon 8. This exon, which we have named exon 8 specifies two stop-codons. mRNAs of the versican gene with exon 8 are predicted to be constitutively degraded by nonsense mediated RNA decay. Here we tested the hypothesis that these transcripts become expressed in a model of neuropathic pain.