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Papers of the Week


Papers: 17 Aug 2019 - 23 Aug 2019


Animal Studies


2019 Oct 15


J Neuroimmunol


335

Murine cytomegalovirus infection in mice results in an acute inflammatory reaction in peripheral nerves.

Authors

Oladiran O, Yang M, Rivera V A G, Shi X Q, Huang J, Fournier S, Zhang J
J Neuroimmunol. 2019 Oct 15; 335:577017.
PMID: 31430710.

Abstract

Human cytomegalovirus (CMV) infection is asymptomatic in immunocompetent individuals. However, it can lead to disease in immunodeficient population. Little is known of the mechanisms underlying the pathogenicity of the virus. We investigated the impact of CMV infection on mouse nervous system. Peripheral nerves but not spinal cord was permissive to MCMV during acute infection. Activated CD8 T cells, monocytes/macrophages and cytokine expression were increased in the blood and sciatic nerves of infected mice, which exhibited transient sensory dysfunction. This study indicates that systemic MCMV infection leads to a dissemination of MCMV into peripheral nerves, which is associated with a local inflammation but not nerve tissue damage in the acute phase.