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Burst and Tonic Spinal Cord Stimulation Both Activate Spinal GABAergic Mechanisms to Attenuate Pain in a Rat Model of Chronic Neuropathic Pain.
Abstract
Experimental and clinical studies have shown that Tonic Spinal Cord Stimulation (SCS) releases GABA in the spinal dorsal horn. Recently, it was suggested that Burst SCS does not act via spinal GABAergic mechanisms. Therefore, we studied spinal GABA-release during Burst and Tonic SCS, both anatomically and pharmacologically, in a well-established chronic neuropathic pain model.