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Papers of the Week

Papers: 10 Aug 2019 - 16 Aug 2019

Human Studies, Pharmacology/Drug Development

2019 Dec

J Arthroplasty



Preemptive Analgesia With Oxycodone Is Associated With More Pain Following Total Joint Arthroplasty.


Cooper JH, Lakra A, Maniker RB, Hickernell TR, Shah RP, Geller JA
J Arthroplasty. 2019 Dec; 34(12):2878-2883.
PMID: 31402074.


Preemptive multimodal analgesia (PMA) is a commonly used technique to control pain following total joint arthroplasty. PMA protocols use multiple analgesics immediately preoperatively to prevent central sensitization and amplification of pain during surgery. While benefits of some individual components of a PMA protocol have been established, there are little data to support inclusion or exclusion of opioids in this context.