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Papers of the Week

Papers: 3 Aug 2019 - 9 Aug 2019

Animal Studies, Pharmacology/Drug Development

2019 Oct

Br J Anaesth



Intrathecal lentivirus-mediated RNA interference targeting nerve growth factor attenuates myocardial ischaemia-reperfusion injury in rat.


Dou M, Ma Z, Cheng X, Zou G, Xu Y, Huang C, Xiong W, He S, Zhang Y
Br J Anaesth. 2019 Oct; 123(4):439-449.
PMID: 31383364.


Nerve growth factor (NGF) has been implicated in hyperalgesia by sensitising nociceptors. A role for NGF in modulating myocardial injury through ischaemic nociceptive signalling is plausible. We examined whether inhibition of spinal NGF attenuates myocardial ischaemia-reperfusion injury and explored the underlying mechanisms.