I am a
Home I AM A Search Login

Papers of the Week


Papers: 3 Aug 2019 - 9 Aug 2019


Animal Studies, Pharmacology/Drug Development


2019 Oct


Br J Anaesth


123


4

Intrathecal lentivirus-mediated RNA interference targeting nerve growth factor attenuates myocardial ischaemia-reperfusion injury in rat.

Authors

Dou M, Ma Z, Cheng X, Zou G, Xu Y, Huang C, Xiong W, He S, Zhang Y
Br J Anaesth. 2019 Oct; 123(4):439-449.
PMID: 31383364.

Abstract

Nerve growth factor (NGF) has been implicated in hyperalgesia by sensitising nociceptors. A role for NGF in modulating myocardial injury through ischaemic nociceptive signalling is plausible. We examined whether inhibition of spinal NGF attenuates myocardial ischaemia-reperfusion injury and explored the underlying mechanisms.