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Papers of the Week

Papers: 3 Aug 2019 - 9 Aug 2019

Human Studies, Pharmacology/Drug Development

2019 Nov

Eur J Pain



Pain inhibitory mechanisms and response to weak analgesics in patients with knee osteoarthritis.


Petersen K K, Simonsen O, Olesen A E, Mørch C D, Arendt-Nielsen L
Eur J Pain. 2019 Nov; 23(10):1904-1912.
PMID: 31376308.


Conditioned pain modulation (CPM) and offset analgesia are different features of descending pain inhibition. This study investigated CPM, offset analgesia and clinical pain measures in patients with knee osteoarthritis (KOA) before and after treatment with the combination of a non-steroidal anti-inflammatory drug (NSAIDs) plus acetaminophen.