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Papers of the Week

Papers: 27 Jul 2019 - 2 Aug 2019

Pharmacology/Drug Development

2019 Jul 29

Curr Pain Headache Rep



Off-label Antidepressant Use for Treatment and Management of Chronic Pain: Evolving Understanding and Comprehensive Review.


Urits I, Peck J, Salisu Orhurhu M, Wolf J, Patel R, Orhurhu V, Kaye AD, Viswanath O
Curr Pain Headache Rep. 2019 Jul 29; 23(9):66.
PMID: 31359175.


While clinicians have been using antidepressants for off-label indications in the treatment of chronic pain in recent years, newer studies have proven effectiveness and provided additional mechanistic understanding and defined potential adverse effects. As depression and chronic pain are frequently comorbid conditions, the use of antidepressants has allowed for treatment of both conditions concomitantly in the same patient population.