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Papers of the Week

Papers: 27 Jul 2019 - 2 Aug 2019

Animal Studies, Pharmacology/Drug Development

2020 Jan

Arthritis Rheumatol



Sepiapterin reductase inhibition selectively reduces inflammatory joint pain and increases urinary sepiapterin.


Fujita M, da Luz Scheffer D, Lenfers Turnes B, Cronin SJF, Latrémolière A, Costigan M, Woolf CJ, Latini A, Andrews NA
Arthritis Rheumatol. 2020 Jan; 72(1):57-66.
PMID: 31350812.


To evaluate the anti-inflammatory and analgesic effect of sepiapterin reductase (SPR) inhibition in a mouse model of inflammatory joint disease and to evaluate sepiapterin as a non-invasive, translational biomarker of SPR inhibition/target engagement in mice and healthy human volunteers.