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Papers of the Week

Papers: 27 Jul 2019 - 2 Aug 2019

2019 Jul 25

Curr Pain Headache Rep



Advances in the Understanding and Management of Chronic Pain in Multiple Sclerosis: a Comprehensive Review.


Urits I, Adamian L, Fiocchi J, Hoyt D, Ernst C, Kaye AD, Viswanath O
Curr Pain Headache Rep. 2019 Jul 25; 23(8):59.
PMID: 31342191.


Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system that can lead to severe physical, cognitive, and neurological deficits that often manifest in young adults. Central neuropathic pain is a common presenting symptom, often prompting patients to seek treatment with opioids, NSAIDS, antiepileptics, and antidepressants despite minimal effectiveness and alarming side-effect profiles. Additionally, spasticity occurs in more than 80% of MS patients and is an important consideration for further study in treatment.