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Papers of the Week

2019 Mar/Apr

J Opioid Manag



Postlaparotomy pain management: Comparison of patient-controlled analgesia pump alone, with subcutaneous bupivacaine infusion, or with injection of liposomal bupivacaine suspension.


Yalmanchili HM, Buchanan SN, Chambers LW, Thorns JD, McKenzie NA, Reiss AD, Page MP, Dizon VV, Brooks SE, Shaffer LE, Lovald ST, Hartranft TH, Price PD
J Opioid Manag. 2019 Mar/Apr; 15(2):169-175.
PMID: 31343718.


Efforts to achieve balance between effective pain management and opioid-related adverse events (ORAEs) have led to multimodal analgesia regimens. This study compared opioids delivered via patient-controlled analgesia (PCA) plus liposomal bupivacaine, a long-acting local anesthetic with potential to be an effective component of such regimens, to opioids delivered through PCA alone or PCA plus subcutaneous bupivacaine infusion (ONQ), following laparotomy.