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Papers of the Week

Papers: 20 Jul 2019 - 26 Jul 2019

Animal Studies, Pharmacology/Drug Development

2019 Oct

Br J Pharmacol



Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain.


Carcolé M, Kummer S, Gonçalves L, Zamanillo D, Merlos M, Dickenson AH, Fernández-Pastor B, Cabañero D, Maldonado R
Br J Pharmacol. 2019 Oct; 176(20):3939-3955.
PMID: 31332781.


Osteoarthritis pain is a chronic disabling condition lacking effective treatment. Continuous use of opioid drugs during osteoarthritis pain induces tolerance and may result in dose escalation and abuse. Sigma-1 receptor (σ1R), a chaperone expressed in key areas for pain control, modulates mu-opioid receptor (MOR) activity and represents a promising target to tackle these problems. The present study investigates the efficacy of σ1R antagonist E-52862 to inhibit pain sensitization, morphine tolerance and associated electrophysiological and molecular changes in a murine model of osteoarthritis pain.