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Papers of the Week

Papers: 20 Jul 2019 - 26 Jul 2019

Animal Studies

2019 Jul 01

J Neurogastroenterol Motil



Vagal Transient Receptor Potential Ankyrin 1 Mediates Stress-exacerbated Visceral Mechanonociception After Antral Cold Exposure.


Chen X, Luo Q, Yan X, Li W, Chen S
J Neurogastroenterol Motil. 2019 Jul 01; 25(3):442-460.
PMID: 31327223.


Abdominal pain can be evoked or exacerbated after gastrointestinal cold stimulation in some patients with diarrhea-predominant irritable bowel syndrome (IBS-D), indicating a low temperature-induced sensitization of visceral perception. We investigated the role of vagal transient receptor potential ankyrin 1 (TRPA1, a cold-sensing ion channel) in cold-aggravated visceral mechanonociception in a stress-induced IBS animal model.