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Papers of the Week
CGRP and Brain Functioning: Cautions for Migraine Treatment.
Authors
PMID: 31328279.
Abstract
Calcitonin gene-related peptide has emerged as a therapeutic target in migraine. Monoclonal antibodies and small molecule receptor antagonists (gepants) directed against CGRP have been approved or are in Phase II or III clinical trials. For monitoring the long-term safety of these drugs, it is helpful to consider the role of CGRP in brain functioning.