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Papers of the Week

2019 Jul 19

Stem Cell Res Ther



Low concentration flufenamic acid enhances osteogenic differentiation of mesenchymal stem cells and suppresses bone loss by inhibition of the NF-κB signaling pathway.


Liu X, Li Z, Liu H, Zhu Y, Xia D, Wang S, Gu R, Wu W, Zhang P, Liu Y, Zhou Y
Stem Cell Res Ther. 2019 Jul 19; 10(1):213.
PMID: 31324207.


As the representative of fenamic acids, an important group of NSAIDs, flufenamic acid (FFA) has been used for anti-inflammation and analgesia in the clinic. Recently, researches have focused on the role of some members of NSAIDs in promoting osteogenesis. However, little attention has been paid to the subgroup of fenamic acids, and it remains unclear whether FFA and other fenamic acids could regulate mesenchymal stem cells' (MSCs) lineage commitment and bone regeneration.