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Papers of the Week


2019 Dec


J Eur Acad Dermatol Venereol


33


12

Phototoxic reaction to brigatinib – a new photosensitizing drug.

Authors

Morgado F, Calvão J, Barata F, Gonçalo M
J Eur Acad Dermatol Venereol. 2019 Dec; 33(12):e491-e492.
PMID: 31325397.

Abstract

We report the case of a 70-year-old woman with metastatic lung adenocarcinoma and meningioma on daily treatment with brigatinib 180mg/day for 6 months and levetiracetam for 10 years. She presented with a 2,5 months history of a pruritic eczematous eruption resembling an exaggerated sunburn involving the face, neck, forearms and hands, sparing non-sun-exposed areas. Limits were not very sharp and pruritus was minor (Fig. 1). She denied exposure to known photosensitizing drugs or airborne chemicals. Routine laboratory tests, antinuclear antibodies, including anti-Ro, were normal. Brigatinib was discontinued and treatment with methylprednisolone 0.5mg/kg/day allowed significant improvement. This article is protected by copyright. All rights reserved.