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Papers of the Week

2019 Oct

Mult Scler Relat Disord


A retrospective cohort study of plasma exchange in central nervous system demyelinating events in children.


Manguinao M, Krysko KM, Maddike S, Rutatangwa A, Francisco C, Hart J, Chong J, Graves JS, Waubant E
Mult Scler Relat Disord. 2019 Oct; 35:50-54.
PMID: 31319355.


Plasma exchange (PLEX) may improve recovery of acute central nervous system (CNS) demyelinating events related to multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), transverse myelitis (TM), acute disseminated encephalomyelitis (ADEM), and MOG-antibody associated demyelination (MOG) if recovery with pulse steroids (PS) is incomplete. Although there is a single randomized controlled trial in adults, there are limited case series in children. We aimed to describe the effectiveness and safety of PLEX in children with acute events of MS, NMOSD, TM, ADEM, and MOG with limited improvement after PS.