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Papers of the Week

Papers: 13 Jul 2019 - 19 Jul 2019

Human Studies

2019 Aug




Impact of an Opioid Safety Initiative on Patients Undergoing Total Knee Arthroplasty: A Time Series Analysis.


Chen Q, Hsia H-L, Overman R, Bryan W, Pepin M, Mariano ER, Mudumbai SC, Buchheit T, Krishnamoorthy V, Good CB, Brookhart AM, Raghunathan K
Anesthesiology. 2019 Aug; 131(2):369-380.
PMID: 31314748.


Opioid overuse remains rampant even in hospitals, but whether administrative opioid safety initiatives reduce use remains unclear WHAT THIS ARTICLE TELLS US THAT IS NEW: The authors evaluated the effects of a Veterans Administration national Opioid Safety Initiative using interrupted time series analysis to compare trends before and after starting the initiativeThere was a trivial increase in pain scores, and a substantial reduction in patients with chronic preoperative and postoperative opioid prescriptions BACKGROUND:: The Opioid Safety Initiative decreased high-dose prescriptions across the Veterans Health Administration. This study sought to examine the impact of this intervention (i.e., the Opioid Safety Initiative) on pain scores and opioid prescriptions in patients undergoing total knee arthroplasty.