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Papers of the Week

Papers: 13 Jul 2019 - 19 Jul 2019

Human Studies

2019 Nov

Eur J Pain



Nerve growth factor-induced muscle hyperalgesia facilitates ischemic contraction-evoked pain.


Sørensen LB, Gazerani P, Graven-Nielsen T
Eur J Pain. 2019 Nov; 23(10):1814-1825.
PMID: 31314952.


Intramuscular injection of Nerve Growth Factor (NGF) may influence the responsiveness of active chemo-sensitive channels affecting muscle pain sensitivity. This double-blinded crossover study in healthy humans assessed contraction-evoked pain responses and pain sensitivity during acute ischemia in the tibialis anterior (TA) muscle before and 24h after five distributed NGF injections (1μg, 4 cm interval) compared with control injections (isotonic-saline).